Dr Rutledge talks about Uric Acid and Death
Dr Rutledge talks about the role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress. Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor, has been in clinical use for over 40 years in the treatment of chronic gout. Allopurinol has also been shown to improve endothelial dysfunction, reduce oxidative stress burden and improve myocardial efficiency by reducing oxygen consumption in smaller mechanistic studies involving various cohorts at risk of cardiovascular events. This article aims to explain the role of xanthine oxidase in vascular oxidative stress and to explore the mechanisms by which allopurinol is thought to improve vascular and myocardial indices. The Mini-Gastric Bypass
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Duration : 0:5:31
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Comments
A very interesting …
A very interesting video Dr Rutledge, Uric acid has been associated with different diseases, like gout, uric acid stones, cardiovascular diseases, etc, In this particular case as mentioned in the video, high levels of uric acid may be an antecedent for a heart attack. Dr Rutledge if you are interested in videos on Medical Topics, or in sharing your videos with medical community you can visit Symposier Site.
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